Hair Growth Regulation: A Molecular Biologic Approach

Title Epidermal growth factor as a biologic switch in hair growth cycle

Epidermal growth factor as a biologic switch in hair growth cycle.

The hair growth cycle consists of three stages known as the anagen (growing), catagen (involution), and telogen (resting) phases. This cyclical growth of hair is regulated by a diversity of growth factors. Although normal expression of both epidermal growth factor and its receptor (EGFR) in the outer root sheath is down-regulated with the completion of follicular growth, here we show that conti...

Biologic therapies in psoriasis: a personalised approach

Psoriasis is a persistent skin disorder characterised by the hyperproliferation of keratinocytes, with development of scaly erythematous plaques. Progressive basic scientific research has led to a better understanding of the pathophysiology, and now dysregulation of the immune system has been identified to be a crucial event in the disease (Figure 1). Attention focusing on more specific targets...

Stable Isotope Ratios in Hair and Teeth Reflect Biologic Rhythms

Biologic rhythms give insight into normal physiology and disease. They can be used as biomarkers for neuronal degenerations. We present a diverse data set to show that hair and teeth contain an extended record of biologic rhythms, and that analysis of these tissues could yield signals of neurodegenerations. We examined hair from mummified humans from South America, extinct mammals and modern an...

Dissecting the genetics of human high myopia: a molecular biologic approach.

PURPOSE Despite the plethora of experimental myopia animal studies that demonstrate biochemical factor changes in various eye tissues, and limited human studies utilizing pharmacologic agents to thwart axial elongation, we have little knowledge of the basic physiology that drives myopic development. Identifying the implicated genes for myopia susceptibility will provide a fundamental molecular ...